LymphedemaV1, Main, Exploration, bibRecord, 007F97

Effects of ivermectin and diethylcarbamazine on microfilariae and overall microfilaria production in bancroftian filariasis.

Identifieur interne : 007F97 ( Main/Exploration ); précédent : 007F96; suivant : 007F98

Effects of ivermectin and diethylcarbamazine on microfilariae and overall microfilaria production in bancroftian filariasis.

Auteurs : Wilma A. Stolk [Pays-Bas] ; Gerrit J. Van Oortmarssen ; S P Pani ; Sake J. De Vlas ; S. Subramanian ; P K Das ; J Dik F. Habbema

Source :

The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2005.

RBID : pubmed:16282298

Descripteurs français

KwdFr :
- Adulte, Animaux, Association de médicaments, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (pharmacologie), Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (administration et posologie), Filaricides (pharmacologie), Filaricides (usage thérapeutique), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (administration et posologie), Ivermectine (pharmacologie), Ivermectine (usage thérapeutique), Microfilaria (), Microfilaria (croissance et développement), Modèles biologiques, Mâle, Méthode en double aveugle, Résultat thérapeutique, Wuchereria bancrofti (), Wuchereria bancrofti (croissance et développement).
MESH :
- administration et posologie : Diéthylcarbamazine, Filaricides, Ivermectine.
- croissance et développement : Microfilaria, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- pharmacologie : Diéthylcarbamazine, Filaricides, Ivermectine.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides, Ivermectine.
- Adulte, Animaux, Association de médicaments, Femelle, Humains, Microfilaria, Modèles biologiques, Mâle, Méthode en double aveugle, Résultat thérapeutique, Wuchereria bancrofti.

English descriptors

KwdEn :
- Adult, Animals, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (pharmacology), Diethylcarbamazine (therapeutic use), Double-Blind Method, Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Female, Filaricides (administration & dosage), Filaricides (pharmacology), Filaricides (therapeutic use), Humans, Ivermectin (administration & dosage), Ivermectin (pharmacology), Ivermectin (therapeutic use), Male, Microfilariae (drug effects), Microfilariae (growth & development), Models, Biological, Treatment Outcome, Wuchereria bancrofti (drug effects), Wuchereria bancrofti (growth & development).
MESH :
- chemical , administration & dosage : Diethylcarbamazine, Filaricides, Ivermectin.
- chemical , pharmacology : Diethylcarbamazine, Filaricides, Ivermectin.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides, Ivermectin.
- drug effects : Microfilariae, Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- growth & development : Microfilariae, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adult, Animals, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Models, Biological, Treatment Outcome.

Abstract

Ivermectin and diethylcarbamazine (DEC) are used in mass treatment programs for the elimination of lymphatic filariasis because of their strong effects on microfilaremia. However, the effects of treatment on adult worms and the degree of individual variation in efficacy are unclear. We analyzed series of microfilaria (Mf) counts from individuals treated with a single dose of 400 microg/kg ivermectin or 6 mg/kg DEC (N = 23 in each group; 1 year follow-up). For each individual, we estimated the microfilaricidal effect and the reduction in overall Mf production (e.g., caused by death or sterilization of worms, or inhibited Mf release from the female worm uterus). Ivermectin on average killed 96% of Mf and reduced Mf production by 82%. DEC killed 57% of Mf and reduced Mf production by 67%, with some individuals responding very poorly. The strong reduction in overall Mf production is good news for control of lymphatic filariasis, but the prospects of elimination will be diminished if part of the population systematically responds poorly to treatment.

PubMed: 16282298

Affiliations:

Le document en format XML

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<term>Diethylcarbamazine (pharmacology)</term>
<term>Diethylcarbamazine (therapeutic use)</term>
<term>Double-Blind Method</term>
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<term>Association de médicaments</term>
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<term>Diéthylcarbamazine (pharmacologie)</term>
<term>Diéthylcarbamazine (usage thérapeutique)</term>
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<term>Filaricides (pharmacologie)</term>
<term>Filaricides (usage thérapeutique)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
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<term>Ivermectine (pharmacologie)</term>
<term>Ivermectine (usage thérapeutique)</term>
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<term>Microfilaria (croissance et développement)</term>
<term>Modèles biologiques</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Résultat thérapeutique</term>
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<term>Filaricides</term>
<term>Ivermectin</term>
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<term>Filaricides</term>
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<term>Wuchereria bancrofti</term>
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<front><div type="abstract" xml:lang="en">Ivermectin and diethylcarbamazine (DEC) are used in mass treatment programs for the elimination of lymphatic filariasis because of their strong effects on microfilaremia. However, the effects of treatment on adult worms and the degree of individual variation in efficacy are unclear. We analyzed series of microfilaria (Mf) counts from individuals treated with a single dose of 400 microg/kg ivermectin or 6 mg/kg DEC (N = 23 in each group; 1 year follow-up). For each individual, we estimated the microfilaricidal effect and the reduction in overall Mf production (e.g., caused by death or sterilization of worms, or inhibited Mf release from the female worm uterus). Ivermectin on average killed 96% of Mf and reduced Mf production by 82%. DEC killed 57% of Mf and reduced Mf production by 67%, with some individuals responding very poorly. The strong reduction in overall Mf production is good news for control of lymphatic filariasis, but the prospects of elimination will be diminished if part of the population systematically responds poorly to treatment.</div>
</front>
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Serveur d'exploration sur le lymphœdème

Effects of ivermectin and diethylcarbamazine on microfilariae and overall microfilaria production in bancroftian filariasis.

Effects of ivermectin and diethylcarbamazine on microfilariae and overall microfilaria production in bancroftian filariasis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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